| ncRNA name | HMGB1 siRNA |
| ncRNA Category | siRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB cell lines Y79 and HXO-RB44; human retinal vascular endothelial cell line ACBRI-181 |
| Methods | qRT-PCR, Western blot, siRNA transfection, MTT assay, flow cytometry |
| Expression pattern | associated |
| Functional description | After siRNA interference HMGB1, the proportion of proliferating cells reduced, and the proportion of quiescent cells increased (P<0.05). In addition, apoptosis rate of Y79 cells increased from 2.03% to 9.10% after interfering with HMGB1 siRNA (P<0.05). |
| PubMed ID | 28149773 |
| Year | 2017 |
| Title | Effect on proliferation and apoptosis of retinoblastoma cell by RNA inhibiting high mobility group protein box-1 expression. |
| Drug-related ncRNA | NO |
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